DCLK1 FISH Probe
The DCLK1 FISH probe is designed to hybridize to the DCLK1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DCLK1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DCLK1-20-RE | 20 (40 μL) | 200 μL |  |
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| DCLK1-20-GO | 20 (40 μL) | 200 μL |  |
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| DCLK1-20-GR | 20 (40 μL) | 200 μL |  |
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| DCLK1-20-AQ | 20 (40 μL) | 200 μL |  |
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| DCLK1-20-DIG | 20 (40 μL) | 200 μL |  |
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| DCLK1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
Gene Details
Gene Symbol: DCLK1
Gene Name: Doublecortin Like Kinase 1
Chromosome: CHR13: 36342788-36705514
Locus: 13q13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DCLK1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DCLK1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping