D430013K02 FISH Probe
The D430013K02 FISH probe is designed to hybridize to the D430013K02 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PREX2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PREX2-20-RE | 20 (40 μL) | 200 μL |  |
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| PREX2-20-GO | 20 (40 μL) | 200 μL |  |
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| PREX2-20-GR | 20 (40 μL) | 200 μL |  |
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| PREX2-20-AQ | 20 (40 μL) | 200 μL |  |
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| PREX2-20-DIG | 20 (40 μL) | 200 μL |  |
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| PREX2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: PREX2
Gene Name: Phosphatidylinositol-3,4,5-trisphosphate Dependent Rac Exchange Factor 2
Chromosome: CHR8: 68864602-69143897
Locus: 8q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: D430013K02 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PREX2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping