D1 FISH Probe
The D1 FISH probe is designed to hybridize to the D1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DIO1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DIO1-20-RE | 20 (40 μL) | 200 μL |  |
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| DIO1-20-GO | 20 (40 μL) | 200 μL |  |
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| DIO1-20-GR | 20 (40 μL) | 200 μL |  |
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| DIO1-20-AQ | 20 (40 μL) | 200 μL |  |
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| DIO1-20-DIG | 20 (40 μL) | 200 μL |  |
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| DIO1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: DIO1
Gene Name: Iodothyronine Deiodinase 1
Chromosome: CHR1: 54359860-54376759
Locus: 1p32.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: D1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DIO1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping