CYSC FISH Probe
The CYSC FISH probe is designed to hybridize to the CYSC gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CST3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CST3-20-RE | 20 (40 μL) | 200 μL |  |
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| CST3-20-GO | 20 (40 μL) | 200 μL |  |
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| CST3-20-GR | 20 (40 μL) | 200 μL |  |
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| CST3-20-AQ | 20 (40 μL) | 200 μL |  |
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| CST3-20-DIG | 20 (40 μL) | 200 μL |  |
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| CST3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]
Gene Details
Gene Symbol: CST3
Gene Name: Cystatin C
Chromosome: CHR20: 23614293-23618574
Locus: 20p11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CYSC FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CST3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping