CYP2D6 FISH Probe
The CYP2D6 FISH probe is designed to hybridize to the CYP2D6 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CYP2D6-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CYP2D6-20-RE | 20 (40 μL) | 200 μL |  |
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| CYP2D6-20-GO | 20 (40 μL) | 200 μL |  |
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| CYP2D6-20-GR | 20 (40 μL) | 200 μL |  |
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| CYP2D6-20-AQ | 20 (40 μL) | 200 μL |  |
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| CYP2D6-20-DIG | 20 (40 μL) | 200 μL |  |
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| CYP2D6-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Details
Gene Symbol: CYP2D6
Gene Name: Cytochrome P450 Family 2 Subfamily D Member 6
Chromosome: CHR22: 42522500-42526883
Locus: 22q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CYP2D6 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CYP2D6-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping