CXXC4 FISH Probe
The CXXC4 FISH probe is designed to hybridize to the CXXC4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CXXC4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CXXC4-20-RE | 20 (40 μL) | 200 μL |  |
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| CXXC4-20-GO | 20 (40 μL) | 200 μL |  |
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| CXXC4-20-GR | 20 (40 μL) | 200 μL |  |
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| CXXC4-20-AQ | 20 (40 μL) | 200 μL |  |
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| CXXC4-20-DIG | 20 (40 μL) | 200 μL |  |
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| CXXC4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Details
Gene Symbol: CXXC4
Gene Name: CXXC Finger Protein 4
Chromosome: CHR4: 105393342-105412467
Locus: 4q24
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CXXC4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CXXC4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping