CTSB FISH Probe
The CTSB FISH probe is designed to hybridize to the CTSB gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CTSB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CTSB-20-RE | 20 (40 μL) | 200 μL |  |
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| CTSB-20-GO | 20 (40 μL) | 200 μL |  |
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| CTSB-20-GR | 20 (40 μL) | 200 μL |  |
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| CTSB-20-AQ | 20 (40 μL) | 200 μL |  |
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| CTSB-20-DIG | 20 (40 μL) | 200 μL |  |
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| CTSB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Gene Details
Gene Symbol: CTSB
Gene Name: Cathepsin B
Chromosome: CHR8: 11700033-11725646
Locus: 8p23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CTSB FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CTSB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping