CRYBA1 FISH Probe
The CRYBA1 FISH probe is designed to hybridize to the CRYBA1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CRYBA1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CRYBA1-20-RE | 20 (40 μL) | 200 μL |  |
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| CRYBA1-20-GO | 20 (40 μL) | 200 μL |  |
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| CRYBA1-20-GR | 20 (40 μL) | 200 μL |  |
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| CRYBA1-20-AQ | 20 (40 μL) | 200 μL |  |
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| CRYBA1-20-DIG | 20 (40 μL) | 200 μL |  |
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| CRYBA1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CRYBA1
Gene Name: Crystallin Beta A1
Chromosome: CHR17: 27573874-27581502
Locus: 17q11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CRYBA1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CRYBA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping