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CREM Break Apart FISH Probe

Empire Genomics’ CREM Break Apart FISH Probe is designed to flank the CREM gene and is typically used for detecting CREM rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
CREMBA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CREMBA-20-AQOR 20 (40 μL) 200 μL
CREMBA-20-GOGR 20 (40 μL) 200 μL
CREMBA-20-GORE 20 (40 μL) 200 μL
CREMBA-20-GRGO 20 (40 μL) 200 μL
CREMBA-20-GROR 20 (40 μL) 200 μL
CREMBA-20-GRRE 20 (40 μL) 200 μL
CREMBA-20-REGO 20 (40 μL) 200 μL
CREMBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: CREM

Gene Name: CAMP Responsive Element Modulator

Chromosome: CHR10: 35415800-35501886

Locus: 10p11.21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor

Clear cell sarcoma can be identified by the fusion of EWSR1 to CREB genes like ATF1 and CREB1. FISH was used to analyze the arrangements of the genes. FISH analysis was performed with our dual-color break apart probes for ATF1, CREB1, and CREM. It was determined that EWSR1-ATF1 fusion was primarily found in clear cell sarcoma in soft tissue, while EWSR1-CREB1 fusion was found in clear cell sarcoma-like gastrointestinal tumors.
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Product Details

Product: CREM FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CREM-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping