CREBL2 Break Apart FISH Probe
Empire Genomics’ CREBL2 Break Apart FISH Probe is designed to flank the CREBL2 gene and is typically used for detecting CREBL2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CREBL2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CREBL2BA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CREBL2
Gene Name: CAMP Responsive Element Binding Protein Like 2
Chromosome: CHR12: 12764830-12798041
Locus: 12p13.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: CREBL2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CREBL2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping