CREBBP FISH Probe
The CREBBP FISH probe is designed to hybridize to the CREBBP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CREBBP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CREBBP-20-RE | 20 (40 μL) | 200 μL |  |
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| CREBBP-20-GO | 20 (40 μL) | 200 μL |  |
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| CREBBP-20-GR | 20 (40 μL) | 200 μL |  |
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| CREBBP-20-AQ | 20 (40 μL) | 200 μL |  |
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| CREBBP-20-DIG | 20 (40 μL) | 200 μL |  |
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| CREBBP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Details
Gene Symbol: CREBBP
Gene Name: CREB Binding Protein
Chromosome: CHR16: 3775055-3930121
Locus: 16p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CREBBP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CREBBP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping