CPSF4 Break Apart FISH Probe
Empire Genomics’ CPSF4 Break Apart FISH Probe is designed to flank the CPSF4 gene and is typically used for detecting CPSF4 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPSF4BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-AQOR | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-GORE | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-GROR | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-REGO | 20 (40 μL) | 200 μL |
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| CPSF4BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CPSF4
Gene Name: Cleavage And Polyadenylation Specific Factor 4
Chromosome: CHR7: 99036562-99054996
Locus: 7q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CPSF4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CPSF4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping