COT FISH Probe
The COT FISH probe is designed to hybridize to the COT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAP3K8-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MAP3K8-20-RE | 20 (40 μL) | 200 μL |  |
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| MAP3K8-20-GO | 20 (40 μL) | 200 μL |  |
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| MAP3K8-20-GR | 20 (40 μL) | 200 μL |  |
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| MAP3K8-20-AQ | 20 (40 μL) | 200 μL |  |
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| MAP3K8-20-DIG | 20 (40 μL) | 200 μL |  |
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| MAP3K8-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Gene Details
Gene Symbol: MAP3K8
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 8
Chromosome: CHR10: 30722949-30750762
Locus: 10p11.23
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: COT FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MAP3K8-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping