COL6A3 FISH Probe
The COL6A3 FISH probe is designed to hybridize to the COL6A3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| COL6A3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| COL6A3-20-RE | 20 (40 μL) | 200 μL |  |
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| COL6A3-20-GO | 20 (40 μL) | 200 μL |  |
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| COL6A3-20-GR | 20 (40 μL) | 200 μL |  |
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| COL6A3-20-AQ | 20 (40 μL) | 200 μL |  |
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| COL6A3-20-DIG | 20 (40 μL) | 200 μL |  |
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| COL6A3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described. [provided by RefSeq, Jun 2009]
Gene Details
Gene Symbol: COL6A3
Gene Name: Collagen Type VI Alpha 3 Chain
Chromosome: CHR2: 238232654-238322850
Locus: 2q37.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: COL6A3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: COL6A3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping