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COL4A3 FISH Probe

The COL4A3 FISH probe is designed to hybridize to the COL4A3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
COL4A3-20-OR  (Standard Design) 20 (40 μL) 200 μL
COL4A3-20-RE 20 (40 μL) 200 μL
COL4A3-20-GO 20 (40 μL) 200 μL
COL4A3-20-GR 20 (40 μL) 200 μL
COL4A3-20-AQ 20 (40 μL) 200 μL
COL4A3-20-DIG 20 (40 μL) 200 μL
COL4A3-20-BIO 20 (40 μL) 200 μL

Gene Summary

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010]

Gene Details

Gene Symbol: COL4A3

Gene Name: Collagen Type IV Alpha 3 Chain

Chromosome: CHR2: 228029280-228179508

Locus: 2q36.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: COL4A3 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: COL4A3-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping