COL4A1 FISH Probe
The COL4A1 FISH probe is designed to hybridize to the COL4A1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| COL4A1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| COL4A1-20-RE | 20 (40 μL) | 200 μL |  |
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| COL4A1-20-GO | 20 (40 μL) | 200 μL |  |
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| COL4A1-20-GR | 20 (40 μL) | 200 μL |  |
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| COL4A1-20-AQ | 20 (40 μL) | 200 μL |  |
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| COL4A1-20-DIG | 20 (40 μL) | 200 μL |  |
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| COL4A1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Details
Gene Symbol: COL4A1
Gene Name: Collagen Type IV Alpha 1 Chain
Chromosome: CHR13: 110801309-110959496
Locus: 13q34
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: COL4A1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: COL4A1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping