COFS4 FISH Probe
The COFS4 FISH probe is designed to hybridize to the COFS4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERCC1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ERCC1-20-RE | 20 (40 μL) | 200 μL |  |
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| ERCC1-20-GO | 20 (40 μL) | 200 μL |  |
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| ERCC1-20-GR | 20 (40 μL) | 200 μL |  |
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| ERCC1-20-AQ | 20 (40 μL) | 200 μL |  |
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| ERCC1-20-DIG | 20 (40 μL) | 200 μL |  |
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| ERCC1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
Gene Details
Gene Symbol: ERCC1
Gene Name: ERCC Excision Repair 1, Endonuclease Non-catalytic Subunit
Chromosome: CHR19: 45910590-45927177
Locus: 19q13.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: COFS4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ERCC1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping