CMT2J FISH Probe
The CMT2J FISH probe is designed to hybridize to the CMT2J gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MPZ-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| MPZ-20-RE | 20 (40 μL) | 200 μL |  |
|
| MPZ-20-GO | 20 (40 μL) | 200 μL |  |
|
| MPZ-20-GR | 20 (40 μL) | 200 μL |  |
|
| MPZ-20-AQ | 20 (40 μL) | 200 μL |  |
|
| MPZ-20-DIG | 20 (40 μL) | 200 μL |  |
|
| MPZ-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]
Gene Details
Gene Symbol: MPZ
Gene Name: Myelin Protein Zero
Chromosome: CHR1: 161274524-161279762
Locus: 1q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: CMT2J FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MPZ-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping