CML FISH Probe
The CML FISH probe is designed to hybridize to the CML gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BCR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BCR-20-RE | 20 (40 μL) | 200 μL |  |
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| BCR-20-GO | 20 (40 μL) | 200 μL |  |
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| BCR-20-GR | 20 (40 μL) | 200 μL |  |
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| BCR-20-AQ | 20 (40 μL) | 200 μL |  |
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| BCR-20-DIG | 20 (40 μL) | 200 μL |  |
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| BCR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: BCR
Gene Name: BCR, RhoGEF And GTPase Activating Protein
Chromosome: CHR22: 23522551-23660224
Locus: 22q11.23
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CML FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BCR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping