CMKAR2 FISH Probe
The CMKAR2 FISH probe is designed to hybridize to the CMKAR2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CXCR2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CXCR2-20-RE | 20 (40 μL) | 200 μL |  |
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| CXCR2-20-GO | 20 (40 μL) | 200 μL |  |
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| CXCR2-20-GR | 20 (40 μL) | 200 μL |  |
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| CXCR2-20-AQ | 20 (40 μL) | 200 μL |  |
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| CXCR2-20-DIG | 20 (40 μL) | 200 μL |  |
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| CXCR2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Gene Details
Gene Symbol: CXCR2
Gene Name: C-X-C Motif Chemokine Receptor 2
Chromosome: CHR2: 218990012-219001976
Locus: 2q35
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CMKAR2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CXCR2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping