CLOCK FISH Probe
The CLOCK FISH probe is designed to hybridize to the CLOCK gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CLOCK-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| CLOCK-20-RE | 20 (40 μL) | 200 μL |  |
|
| CLOCK-20-GO | 20 (40 μL) | 200 μL |  |
|
| CLOCK-20-GR | 20 (40 μL) | 200 μL |  |
|
| CLOCK-20-AQ | 20 (40 μL) | 200 μL |  |
|
| CLOCK-20-DIG | 20 (40 μL) | 200 μL |  |
|
| CLOCK-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Details
Gene Symbol: CLOCK
Gene Name: Clock Circadian Regulator
Chromosome: CHR4: 56298659-56412997
Locus: 4q12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: CLOCK FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CLOCK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping