CLDN16 FISH Probe
The CLDN16 FISH probe is designed to hybridize to the CLDN16 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CLDN16-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CLDN16-20-RE | 20 (40 μL) | 200 μL |  |
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| CLDN16-20-GO | 20 (40 μL) | 200 μL |  |
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| CLDN16-20-GR | 20 (40 μL) | 200 μL |  |
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| CLDN16-20-AQ | 20 (40 μL) | 200 μL |  |
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| CLDN16-20-DIG | 20 (40 μL) | 200 μL |  |
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| CLDN16-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]
Gene Details
Gene Symbol: CLDN16
Gene Name: Claudin 16
Chromosome: CHR3: 190105660-190129932
Locus: 3q28
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CLDN16 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CLDN16-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping