CLCN3 FISH Probe
The CLCN3 FISH probe is designed to hybridize to the CLCN3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CLCN3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CLCN3-20-RE | 20 (40 μL) | 200 μL |  |
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| CLCN3-20-GO | 20 (40 μL) | 200 μL |  |
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| CLCN3-20-GR | 20 (40 μL) | 200 μL |  |
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| CLCN3-20-AQ | 20 (40 μL) | 200 μL |  |
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| CLCN3-20-DIG | 20 (40 μL) | 200 μL |  |
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| CLCN3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: CLCN3
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671-170644338
Locus: 4q33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CLCN3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CLCN3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping