CLAC FISH Probe
The CLAC FISH probe is designed to hybridize to the CLAC gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| COL25A1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-RE | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-GO | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-GR | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-AQ | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-DIG | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Details
Gene Symbol: COL25A1
Gene Name: Collagen Type XXV Alpha 1 Chain
Chromosome: CHR4: 109734971-110223799
Locus: 4q25
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CLAC FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: COL25A1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping