CHRNB3 FISH Probe
The CHRNB3 FISH probe is designed to hybridize to the CHRNB3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHRNB3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CHRNB3-20-RE | 20 (40 μL) | 200 μL |  |
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| CHRNB3-20-GO | 20 (40 μL) | 200 μL |  |
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| CHRNB3-20-GR | 20 (40 μL) | 200 μL |  |
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| CHRNB3-20-AQ | 20 (40 μL) | 200 μL |  |
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| CHRNB3-20-DIG | 20 (40 μL) | 200 μL |  |
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| CHRNB3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]
Gene Details
Gene Symbol: CHRNB3
Gene Name: Cholinergic Receptor Nicotinic Beta 3 Subunit
Chromosome: CHR8: 42552561-42592209
Locus: 8p11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CHRNB3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CHRNB3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping