CHEK2 FISH Probe
The CHEK2 FISH probe is designed to hybridize to the CHEK2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHEK2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CHEK2-20-RE | 20 (40 μL) | 200 μL |  |
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| CHEK2-20-GO | 20 (40 μL) | 200 μL |  |
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| CHEK2-20-GR | 20 (40 μL) | 200 μL |  |
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| CHEK2-20-AQ | 20 (40 μL) | 200 μL |  |
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| CHEK2-20-DIG | 20 (40 μL) | 200 μL |  |
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| CHEK2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Details
Gene Symbol: CHEK2
Gene Name: Checkpoint Kinase 2
Chromosome: CHR22: 29083730-29137822
Locus: 22q12.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CHEK2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CHEK2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping