CHCHD2 FISH Probe
The CHCHD2 FISH probe is designed to hybridize to the CHCHD2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHCHD2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CHCHD2-20-RE | 20 (40 μL) | 200 μL |  |
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| CHCHD2-20-GO | 20 (40 μL) | 200 μL |  |
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| CHCHD2-20-GR | 20 (40 μL) | 200 μL |  |
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| CHCHD2-20-AQ | 20 (40 μL) | 200 μL |  |
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| CHCHD2-20-DIG | 20 (40 μL) | 200 μL |  |
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| CHCHD2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: CHCHD2
Gene Name: Coiled-coil-helix-coiled-coil-helix Domain Containing 2
Chromosome: CHR7: 56169265-56174187
Locus: 7p11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CHCHD2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CHCHD2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping