CG43122-PD FISH Probe
The CG43122-PD FISH probe is designed to hybridize to the CG43122-PD gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CIC-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CIC-20-RE | 20 (40 μL) | 200 μL |  |
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| CIC-20-GO | 20 (40 μL) | 200 μL |  |
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| CIC-20-GR | 20 (40 μL) | 200 μL |  |
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| CIC-20-AQ | 20 (40 μL) | 200 μL |  |
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| CIC-20-DIG | 20 (40 μL) | 200 μL |  |
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| CIC-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Details
Gene Symbol: CIC
Gene Name: Capicua Transcriptional Repressor
Chromosome: CHR19: 42788816-42799949
Locus: 19q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CG43122-PD FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CIC-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping