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CDKN2A Break Apart FISH Probe

Empire Genomics’ CDKN2A Break Apart FISH Probe is designed to flank the CDKN2A gene and is typically used for detecting CDKN2A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
CDKN2ABA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
CDKN2ABA-20-AQOR 20 (40 μL) 200 μL
CDKN2ABA-20-GOGR 20 (40 μL) 200 μL
CDKN2ABA-20-GORE 20 (40 μL) 200 μL
CDKN2ABA-20-GRGO 20 (40 μL) 200 μL
CDKN2ABA-20-GRRE 20 (40 μL) 200 μL
CDKN2ABA-20-ORGR 20 (40 μL) 200 μL
CDKN2ABA-20-REGO 20 (40 μL) 200 μL
CDKN2ABA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Gene Details

Gene Symbol: CDKN2A

Gene Name: Cyclin Dependent Kinase Inhibitor 2A

Chromosome: CHR9: 21967750-21994490

Locus: 9p21.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Product Details

Product: CDKN2A FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CDKN2A-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping