CDKN1A Break Apart FISH Probe
Empire Genomics’ CDKN1A Break Apart FISH Probe is designed to flank the CDKN1A gene and is typically used for detecting CDKN1A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
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CDKN1ABA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-AQOR | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-GOGR | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-GORE | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-GRGO | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-GROR | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-GRRE | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-REGO | 20 (40 μL) | 200 μL | ||
CDKN1ABA-20-REGR | 20 (40 μL) | 200 μL |
Gene Summary
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
Gene Details
Gene Symbol: CDKN1A
Gene Name: Cyclin Dependent Kinase Inhibitor 1A
Chromosome: CHR6: 36644236-36655116
Locus: 6p21.2
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CDKN1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CDKN1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping