CDK5P35 FISH Probe
The CDK5P35 FISH probe is designed to hybridize to the CDK5P35 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDK5R1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CDK5R1-20-RE | 20 (40 μL) | 200 μL |  |
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| CDK5R1-20-GO | 20 (40 μL) | 200 μL |  |
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| CDK5R1-20-GR | 20 (40 μL) | 200 μL |  |
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| CDK5R1-20-AQ | 20 (40 μL) | 200 μL |  |
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| CDK5R1-20-DIG | 20 (40 μL) | 200 μL |  |
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| CDK5R1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CDK5R1
Gene Name: Cyclin Dependent Kinase 5 Regulatory Subunit 1
Chromosome: CHR17: 30814104-30818271
Locus: 17q11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CDK5P35 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CDK5R1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping