CDK4I FISH Probe
The CDK4I FISH probe is designed to hybridize to the CDK4I gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDKN2A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CDKN2A-20-RE | 20 (40 μL) | 200 μL |  |
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| CDKN2A-20-GO | 20 (40 μL) | 200 μL |  |
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| CDKN2A-20-GR | 20 (40 μL) | 200 μL |  |
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| CDKN2A-20-AQ | 20 (40 μL) | 200 μL |  |
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| CDKN2A-20-DIG | 20 (40 μL) | 200 μL |  |
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| CDKN2A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Gene Details
Gene Symbol: CDKN2A
Gene Name: Cyclin Dependent Kinase Inhibitor 2A
Chromosome: CHR9: 21967750-21994490
Locus: 9p21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CDK4I FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CDKN2A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping