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CDK4 FISH Probe

The CDK4 FISH probe is designed to hybridize to the CDK4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
CDK4-20-OR  (Standard Design) 20 (40 μL) 200 μL
CDK4-20-RE 20 (40 μL) 200 μL
CDK4-20-GO 20 (40 μL) 200 μL
CDK4-20-GR 20 (40 μL) 200 μL
CDK4-20-AQ 20 (40 μL) 200 μL
CDK4-20-DIG 20 (40 μL) 200 μL
CDK4-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: CDK4

Gene Name: Cyclin Dependent Kinase 4

Chromosome: CHR12: 58141509-58146230

Locus: 12q14.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
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Analysis of mucosal melanoma whole-genome landscapes reveals clinically relevant genomic aberrations

Unlike cutaneous melanoma, the genomics of mucosal melanoma (MM) remain poorly understood, which has hindered the development of targeted therapy for MM patients. In order to account for this gap in data, this team performed whole-genome sequencing on 65 MM samples to identify genomic alterations with prognostic and/or therapeutic implications. Our CDK4 and TERT probes were used to detect amplification of the genes.
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Product Details

Product: CDK4 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CDK4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping