CD42C FISH Probe
The CD42C FISH probe is designed to hybridize to the CD42C gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GP1BB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| GP1BB-20-RE | 20 (40 μL) | 200 μL |  |
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| GP1BB-20-GO | 20 (40 μL) | 200 μL |  |
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| GP1BB-20-GR | 20 (40 μL) | 200 μL |  |
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| GP1BB-20-AQ | 20 (40 μL) | 200 μL |  |
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| GP1BB-20-DIG | 20 (40 μL) | 200 μL |  |
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| GP1BB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010]
Gene Details
Gene Symbol: GP1BB
Gene Name: Glycoprotein Ib Platelet Beta Subunit
Chromosome: CHR22: 19711065-19712297
Locus: 22q11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CD42C FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GP1BB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping