CD274 Break Apart FISH Probe
Empire Genomics’ CD274 Break Apart FISH Probe is designed to flank the CD274 gene and is typically used for detecting CD274 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD274BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD274BA-20-AQOR | 20 (40 μL) | 200 μL |
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| CD274BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CD274BA-20-GORE | 20 (40 μL) | 200 μL |
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| CD274BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CD274BA-20-GROR | 20 (40 μL) | 200 μL |
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| CD274BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CD274BA-20-REGO | 20 (40 μL) | 200 μL |
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| CD274BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Details
Gene Symbol: CD274
Gene Name: CD274 Molecule
Chromosome: CHR9: 5450502-5470567
Locus: 9p24.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CD274 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CD274-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping