CD254 FISH Probe
The CD254 FISH probe is designed to hybridize to the CD254 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFSF11-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TNFSF11-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFSF11-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFSF11-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFSF11-20-AQ | 20 (40 μL) | 200 μL |  |
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| TNFSF11-20-DIG | 20 (40 μL) | 200 μL |  |
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| TNFSF11-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: TNFSF11
Gene Name: TNF Superfamily Member 11
Chromosome: CHR13: 43136871-43182149
Locus: 13q14.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CD254 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TNFSF11-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping