CD253 FISH Probe
The CD253 FISH probe is designed to hybridize to the CD253 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNFSF10-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TNFSF10-20-RE | 20 (40 μL) | 200 μL |  |
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| TNFSF10-20-GO | 20 (40 μL) | 200 μL |  |
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| TNFSF10-20-GR | 20 (40 μL) | 200 μL |  |
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| TNFSF10-20-AQ | 20 (40 μL) | 200 μL |  |
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| TNFSF10-20-DIG | 20 (40 μL) | 200 μL |  |
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| TNFSF10-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Details
Gene Symbol: TNFSF10
Gene Name: TNF Superfamily Member 10
Chromosome: CHR3: 172223297-172241297
Locus: 3q26.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CD253 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TNFSF10-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping