CD246 FISH Probe
The CD246 FISH probe is designed to hybridize to the CD246 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ALK-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ALK-20-RE | 20 (40 μL) | 200 μL |  |
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| ALK-20-GO | 20 (40 μL) | 200 μL |  |
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| ALK-20-GR | 20 (40 μL) | 200 μL |  |
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| ALK-20-AQ | 20 (40 μL) | 200 μL |  |
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| ALK-20-DIG | 20 (40 μL) | 200 μL |  |
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| ALK-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Gene Details
Gene Symbol: ALK
Gene Name: ALK Receptor Tyrosine Kinase
Chromosome: CHR2: 29415639-30144477
Locus: 2p23.2-p23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CD246 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ALK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping