CD135 FISH Probe
The CD135 FISH probe is designed to hybridize to the CD135 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FLT3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FLT3-20-RE | 20 (40 μL) | 200 μL |  |
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| FLT3-20-GO | 20 (40 μL) | 200 μL |  |
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| FLT3-20-GR | 20 (40 μL) | 200 μL |  |
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| FLT3-20-AQ | 20 (40 μL) | 200 μL |  |
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| FLT3-20-DIG | 20 (40 μL) | 200 μL |  |
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| FLT3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Gene Details
Gene Symbol: FLT3
Gene Name: Fms Related Tyrosine Kinase 3
Chromosome: CHR13: 28577410-28674729
Locus: 13q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CD135 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FLT3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping