CCND2 FISH Probe
The CCND2 FISH probe is designed to hybridize to the CCND2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CCND2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CCND2-20-RE | 20 (40 μL) | 200 μL |  |
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| CCND2-20-GO | 20 (40 μL) | 200 μL |  |
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| CCND2-20-GR | 20 (40 μL) | 200 μL |  |
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| CCND2-20-AQ | 20 (40 μL) | 200 μL |  |
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| CCND2-20-DIG | 20 (40 μL) | 200 μL |  |
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| CCND2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
Gene Details
Gene Symbol: CCND2
Gene Name: Cyclin D2
Chromosome: CHR12: 4382901-4414522
Locus: 12p13.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
A patient with a diagnosis of nodal marginal zone B-cell lymphoma and a t(2;14)(p24;q32) involving MYCN and IGH
Product Details
Product: CCND2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CCND2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping