CCM2 FISH Probe
The CCM2 FISH probe is designed to hybridize to the CCM2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CCM2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CCM2-20-RE | 20 (40 μL) | 200 μL |  |
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| CCM2-20-GO | 20 (40 μL) | 200 μL |  |
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| CCM2-20-GR | 20 (40 μL) | 200 μL |  |
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| CCM2-20-AQ | 20 (40 μL) | 200 μL |  |
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| CCM2-20-DIG | 20 (40 μL) | 200 μL |  |
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| CCM2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Gene Details
Gene Symbol: CCM2
Gene Name: CCM2 Scaffolding Protein
Chromosome: CHR7: 45039344-45116069
Locus: 7p13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CCM2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CCM2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping