CBL FISH Probe
The CBL FISH probe is designed to hybridize to the CBL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CBL-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CBL-20-RE | 20 (40 μL) | 200 μL |  |
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| CBL-20-GO | 20 (40 μL) | 200 μL |  |
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| CBL-20-GR | 20 (40 μL) | 200 μL |  |
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| CBL-20-AQ | 20 (40 μL) | 200 μL |  |
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| CBL-20-DIG | 20 (40 μL) | 200 μL |  |
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| CBL-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: CBL
Gene Name: Cbl Proto-oncogene
Chromosome: CHR11: 119076989-119178859
Locus: 11q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CBL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CBL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping