CBFB FISH Probe
The CBFB FISH probe is designed to hybridize to the CBFB gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CBFB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CBFB-20-RE | 20 (40 μL) | 200 μL |  |
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| CBFB-20-GO | 20 (40 μL) | 200 μL |  |
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| CBFB-20-GR | 20 (40 μL) | 200 μL |  |
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| CBFB-20-AQ | 20 (40 μL) | 200 μL |  |
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| CBFB-20-DIG | 20 (40 μL) | 200 μL |  |
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| CBFB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CBFB
Gene Name: Core-binding Factor Beta Subunit
Chromosome: CHR16: 67063049-67134958
Locus: 16q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CBFB FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CBFB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping