CASP8 Break Apart FISH Probe
Empire Genomics’ CASP8 Break Apart FISH Probe is designed to flank the CASP8 gene and is typically used for detecting CASP8 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CASP8BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CASP8BA-20-AQOR | 20 (40 μL) | 200 μL |
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| CASP8BA-20-GOGR | 20 (40 μL) | 200 μL |
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| CASP8BA-20-GORE | 20 (40 μL) | 200 μL |
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| CASP8BA-20-GRGO | 20 (40 μL) | 200 μL |
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| CASP8BA-20-GROR | 20 (40 μL) | 200 μL |
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| CASP8BA-20-GRRE | 20 (40 μL) | 200 μL |
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| CASP8BA-20-REGO | 20 (40 μL) | 200 μL |
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| CASP8BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CASP8
Gene Name: Caspase 8
Chromosome: CHR2: 202098165-202152434
Locus: 2q33.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CASP8 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CASP8-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping