CASP8-1 FISH Probe
The CASP8-1 FISH probe is designed to hybridize to the CASP8-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CASP8-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CASP8-20-RE | 20 (40 μL) | 200 μL |  |
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| CASP8-20-GO | 20 (40 μL) | 200 μL |  |
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| CASP8-20-GR | 20 (40 μL) | 200 μL |  |
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| CASP8-20-AQ | 20 (40 μL) | 200 μL |  |
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| CASP8-20-DIG | 20 (40 μL) | 200 μL |  |
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| CASP8-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CASP8
Gene Name: Caspase 8
Chromosome: CHR2: 202098165-202152434
Locus: 2q33.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CASP8-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CASP8-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping