CACNL1A4 FISH Probe
The CACNL1A4 FISH probe is designed to hybridize to the CACNL1A4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CACNA1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CACNA1A-20-RE | 20 (40 μL) | 200 μL |  |
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| CACNA1A-20-GO | 20 (40 μL) | 200 μL |  |
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| CACNA1A-20-GR | 20 (40 μL) | 200 μL |  |
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| CACNA1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| CACNA1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| CACNA1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: CACNA1A
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 A
Chromosome: CHR19: 13317255-13617274
Locus: 19p13.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CACNL1A4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CACNA1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping