C77457 FISH Probe
The C77457 FISH probe is designed to hybridize to the C77457 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| INCENP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| INCENP-20-RE | 20 (40 μL) | 200 μL |  |
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| INCENP-20-GO | 20 (40 μL) | 200 μL |  |
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| INCENP-20-GR | 20 (40 μL) | 200 μL |  |
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| INCENP-20-AQ | 20 (40 μL) | 200 μL |  |
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| INCENP-20-DIG | 20 (40 μL) | 200 μL |  |
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| INCENP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Gene Details
Gene Symbol: INCENP
Gene Name: Inner Centromere Protein
Chromosome: CHR11: 61891444-61920635
Locus: 11q12.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: C77457 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: INCENP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping