C4BR FISH Probe
The C4BR FISH probe is designed to hybridize to the C4BR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CR1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CR1-20-RE | 20 (40 μL) | 200 μL |  |
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| CR1-20-GO | 20 (40 μL) | 200 μL |  |
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| CR1-20-GR | 20 (40 μL) | 200 μL |  |
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| CR1-20-AQ | 20 (40 μL) | 200 μL |  |
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| CR1-20-DIG | 20 (40 μL) | 200 μL |  |
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| CR1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: CR1
Gene Name: Complement C3b/C4b Receptor 1 (Knops Blood Group)
Chromosome: CHR1: 207669472-207815110
Locus: 1q32.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: C4BR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CR1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping