BRCA2 FISH Probe
The BRCA2 FISH probe is designed to hybridize to the BRCA2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BRCA2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BRCA2-20-RE | 20 (40 μL) | 200 μL |  |
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| BRCA2-20-GO | 20 (40 μL) | 200 μL |  |
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| BRCA2-20-GR | 20 (40 μL) | 200 μL |  |
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| BRCA2-20-AQ | 20 (40 μL) | 200 μL |  |
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| BRCA2-20-DIG | 20 (40 μL) | 200 μL |  |
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| BRCA2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
Gene Details
Gene Symbol: BRCA2
Gene Name: BRCA2, DNA Repair Associated
Chromosome: CHR13: 32889616-32973809
Locus: 13q13.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BRCA2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BRCA2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping