BCO3 FISH Probe
The BCO3 FISH probe is designed to hybridize to the BCO3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RPE65-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RPE65-20-RE | 20 (40 μL) | 200 μL |  |
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| RPE65-20-GO | 20 (40 μL) | 200 μL |  |
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| RPE65-20-GR | 20 (40 μL) | 200 μL |  |
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| RPE65-20-AQ | 20 (40 μL) | 200 μL |  |
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| RPE65-20-DIG | 20 (40 μL) | 200 μL |  |
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| RPE65-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]
Gene Details
Gene Symbol: RPE65
Gene Name: RPE65, Retinoid Isomerohydrolase
Chromosome: CHR1: 68894506-68915642
Locus: 1p31.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BCO3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RPE65-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping